您现在的位置: 首页 >> 成员介绍 -> 前组员
曾乐勇 博士 副研究员 硕士生导师
日期:2016-05-16, 查看:5832

                                                              

2001.09-2005.06,河北大学物理科学与技术学院,获理学学士学位。
2005.09-2010.06,中国科学院长春光学精密机械与物理研究所,获理学博士学位 。
2010.04-2012.12,中国科学院宁波材料技术与工程研究所,助理研究员。
2012.12-2016.07,中国科学院宁波材料技术与工程研究所,副研究员。
2016.07-今,中国科学院宁波材料技术与工程研究所,客聘研究员。

    主要从事纳米材料制备及其在医学成像与治疗中的应用研究。迄今已在Biomaterials等期刊发表学术论文39篇,申请专利14件(已授权10件),主要研究方向包括MRI造影剂材料及应用、具有光动力治疗功能的多功能MRI造影剂材料及应用、近红外光激发的TiO2基无机光敏剂及光动力治疗应用等。主持国家自然科学基金2项、浙江省公益性项目1项、宁波市自然科学基金2项、中科院宁波材料所所长基金等项目。是ACS Appl. Mater. Interf., Chem. Common, Nanoscale, J. Mater. Chem., RSC Adv., IEEE T. Med. Imaging杂志审稿人,是中国生物物理学会、中国生物材料学会会员。2010-2014年,连续五年被评为中科院宁波材料所优秀员工。

联系方式:电话:0574-86685513,E-mail:zengly@nimte.ac.cn

主持项目:
1.近红外光激发的TiO2基无机光敏剂及其肿瘤靶向光动力治疗研究.国家自然科学基金,2014.01-2016.12. 70万元
2.以NaGdF4为骨架的纳米载体用于MRI引导的耐药乳腺癌近红外光动力治疗和化疗研究. 浙江省公益性项目,2015.01-2016.12. 15万元
3.中科院青年创新促进会,2015.01-2018.12. 40万元
4.乳腺癌多功能分子探针及临床诊疗关键技术研究. 宁波市科技富民惠民项目,2015.06-2018.05, 总经费40万元,合作单位负责人(牵头单位:宁波市第二医院)
5.基于超顺磁-上转换发光复合纳米粒子的多功能磁共振造影材料研究. 国家自然科学基金,2012.01-2014.12. 25万元(已结题)
6.水溶性Fe3O4-TiO2复合纳米粒子的可控制备及其多功能磁共振造影剂应用研究. 中国博士后科学基金一等资助,2010.05-2012.05. 5+5万元(已结题)
7.水溶性的超顺磁铁-钛氧化物复合纳米粒子的可控制备、组分调控及其在磁共振成像造影剂中的应用研究. 宁波市自然科学基金,2010.02-2012.01. 4万元(已结题)
8.基于能量传递原理的TiO2-NaYF4:Yb3+/Tm3+复合纳米粒子制备及其光动力治疗应用研究. 中科院宁波材料所所长基金,2012.01-2013.12. 20万元(已结题)
9.基于能量传递原理的TiO2-NaYF4:Yb3+/Tm3+复合纳米粒子制备及其在光动力治疗中的应用研究. 宁波市自然科学基金,2012.05-2014.04. 5万元(已结题)

获得荣誉:
1. 2010年,中科院院长优秀奖。
2. 2012年,宁波市领军和拔尖人才工程第三层次(2014年中期考核优秀)。
3. 2014年,中科院宁波材料所“春蕾人才”。
4. 2015年,中科院青年创新促进会会员。
5. 2015年,宁波市领军和拔尖人才工程第二层次。

主要论文:
1. Leyong Zeng, Yuanwei Pan, Shouju Wang, Xin Wang, Xinmei Zhao, Wenzhi Ren, Guangming Lu*, Aiguo Wu*. Raman reporter-coupled Agcore@Aushell
nanostars for in vivo improved surface enhanced Raman scattering imaging and near-infrared-triggered photothermal therapy in breast cancers. ACS Appl. Mater. Interfaces 2015, in press.
2. Leyong Zeng, Lijia Luo, Yuanwei Pan, Song Luo, Guangming Lu*, Aiguo Wu*. In vivo targeted magnetic resonance imaging and visualized photodynamic
therapy in deep-tissue cancers using folic acid-functionalized superparamagnetic-upconversion nanocomposites. Nanoscale 2015, 7, 8946-8954.
3. Leyong Zeng, Yuanwei Pan, Ying Tian, Xin Wang, Wenzhi Ren, Shouju Wang, Guangming Lu*, Aiguo Wu*. Doxorubicin-loaded NaYF4:Yb/Tm-TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers. Biomaterials 2015, 57, 93-106.
4. Wenzhi Ren, Yong Yan, Leyong Zeng, Zhenzhi Shi, An Gong, Peter Schaaf, Dong Wang*, Jinshun Zhao, Baobo Zou, Hongsheng Yu, Ge Chen*, Eric Michael Bratsolias Brown, Aiguo Wu*. A near infrared light triggered hydrogenated black TiO2 for cancer photothermal therapy. Adv. Healthcare Mater. 2015, 4, 1526–1536.201500273.
5. Ying Tian, Song Luo, Huaijiang Yan, Zhaogang Teng, Yuanwei Pan, Leyong Zeng, Jiang Wu, Yanjun Li, Ying Liu, Shouju Wang*, Guangming Lu*. Amine-terminated PEG Functionalized Gold Nanostars for X-ray/CT Imaging and Photothermal Therapy. J.Mater. Chem. B 2015, 3, 4330-4337.
6. Ling"e Zhang, Leyong Zeng*, Yuanwei Pan, Song Luo, Wenzhi Ren, An Gong, Xuehua Ma, Hongze Liang, Guangming Lu*, Aiguo Wu*. Inorganic photosensitizer coupled Gd-based upconversion luminescent nanocomposites for in vivo magnetic resonance imaging and near-infrared-responsive photodynamic therapy in cancers. Biomaterials 2015, 44, 82-90.
7. Yang Du, Wenzhi Ren, Yaqian Lia, Qian Zhang, Leyong Zeng, Chongwei Chi, Aiguo Wu*, Jie Tian*. The Enhanced Chemotherapeutic Effects of Doxorubicin Nanocarriers in an Orthotopic Breast Tumor Bearing Mouse Model. J. Mater. Chem. B 2015, 3, 1518-1528.
8. Ying Tian, Jing Sun, Huaijiang Yan, Zhaogang Teng, Leyong Zeng, Ying Liu, Yanjun Li, Jiandong Wang, Shouju Wang*, Guangming Lu*. A rapid and convenient method for detecting a broad spectrum of malignant cells from malignant pleuroperitoneal effusion of patients using a multifunctional NIR heptamethine dye. Analyst, 2015, 140, 750-755.
9. Leyong Zeng*, Lingchao Xiang, Wenzhi Ren, Jianjun Zheng, Tianhua Li, Bin Chen, Jichao Zhang, Chengwen Mao, Aiguo Li, Aiguo Wu*. Multifunctional photosensitizer-conjugated core-shell Fe3O4@NaYF4:Yb/Er nanocomplexes and their applications in T2-weighted magnetic resonance /upconversion luminescence imaging and photodynamic therapy of cancer cells. RSC Advances 2013, 3, 13915-13925.
10. Wenzhi Ren, Leyong Zeng, Zheyu Shen, Lingchao Xiang, An Gong, Jichao Zhang, Chengwen Mao, Aiguo Li, Tatjana Paunesku, Gayle E.Woloschak, Narayan S. Hosmane, Aiguo Wu*. Enhanced Doxorubicin Transport to Multidrug Resistant Breast Cancer Cells via TiO2 Nanocarriers. RSC Advances 2013, 3, 20855-20861.
11. Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Jianjun Zheng, Bin Chen, Aiguo Wu*. Multifunctional Fe3O4-TiO2 nanocomposites for magnetic resonance imaging and potential photodynamic therapy. Nanoscale 2013, 5, 2107-2113.
12. Leyong Zeng*, Wenzhi Ren, Jianjun Zheng, Aiguo Wu*, Ping Cui. Synthesis of water-soluble FeOOH nanospindles and their performance for magnetic resonance imaging. Appl. Surf. Sci. 2012, 258, 2570-2575.
13. Leyong Zeng, Wenzhi Ren, Jianjun Zheng*, Ping Cui, Aiguo Wu*. Ultrasmall water-soluble metal-iron oxide nanoparticles as T1-weighted contrast agents of magnetic resonance imaging. Phys. Chem. Chem. Phys. 2012, 14, 2631-2636.
14. Leyong Zeng, Aiguo Wu*, Yazhuo Wang, Shiliu Pu, Jiandong Ding. In-situ observation and relocation method of nanomaterial samples based on microscope system. Microsc. Res. Techniq. 2012, 75, 138-144.
15. Jay Blatnik, Lanette Luebke, Stephanie Simonet, Megan Nelson, Race Price, Rachael Leek, Leyong Zeng, Aiguo Wu, Eric M.B. Brown*. Dye surface coating enables visible light activation of TiO2 nanoparticles leading to degradation of neighboring biological structures. Microsc. Microanal. 2012, 18, 134-142.
16. Fuqiang Zhang, Leyong Zeng, Yingxin Zhang, Haiyan Wang*, Aiguo Wu*. A colorimetric assay method for Co2+ based on thioglycolic acid functionalized hexadecyl trimethyl ammonium bromide modified Au nanoparticles(NPs). Nanoscale 2011, 3, 2150-2154.
17. Fuqiang Zhang, Leyong Zeng, Cui Yang, Junwei Xin, Haiyan Wang*, Aiguo Wu*. A one-Step colorimetric method of analysis detection of Hg2+ based on an in-situ formation of Au@HgS core-shell structures. Analyst 2011, 136, 2825-2830.
18. Aiguo Wu*, Ping Ou, Leyong Zeng. Biomedical applications of magnetic nanoparticles. NANO 2010, 5, 245-270.
19. Leyong Zeng, Weibiao Wang*, Da Lei, Jingqiu Liang, Yuxue Xia, Haifeng Zhao, Xianggui Kong, Jialong Zhao. The effect of carbon microfiber substratepretreatment on the growth of carbon nanomaterials. Carbon 2008, 46: 359-364.
20. Leyong Zeng, Hongyan Peng, Weibiao Wang*, Yuqiang Chen, Da Lei, Wentao Qi, Jingqiu Liang, Jialong Zhao, Xianggui Kong, Hong Zhang. Nanocrystalline diamond films deposited by the hot cathode direct current plasma chemical vapor deposition method with different compositions of CH4/Ar/H2 gas mixture. J .Phys. Chem. C 2008, 112: 1401-1406.
21. Leyong Zeng, Hongyan Peng, Weibiao Wang*, Yuqiang Chen, Da Lei, Wentao Qi, Jingqiu Liang, Jialong Zhao, Xianggui Kong, Hong Zhang. Synthesis and characterization of diamond microcrystals and nanorods deposited by hot cathode direct current plasma chemical vapor deposition method. J .Phys. Chem. C 2008, 112: 6160-6164.
22. Leyong Zeng, Hongyan Peng, Weibiao Wang*, Yuqiang Chen, Wentao Qi, Da Lei, Jingqiu Liang, Jialong Zhao, Xianggui Kong. Direct current discharge plasma chemical vapor deposition of nanocrystalline graphite films on carbon fibers. J .Phys. Chem. C 2008, 112:10735-10739.
23. Leyong Zeng, Weibiao Wang*, Jingqiu Liang, Zhiqian Wang, Yuxue Xia, Da Lei, Xinguang Ren, Ning Yao, Binglin Zhang. The changes of morphology, structure and optical properties from carbon nanotubes treated by hydrogen plasma. Materials Chemistry and Physics 2008, 108: 82-87.
24. Leyong Zeng, Weibiao Wang*, Da Lei, Jingqiu Liang, Haifeng Zhao, Xianggui Kong, Jialong Zhao. Carbon submicrotubes synthesized on carbon microfibers. Thin Solid Films 2008, 516:7323-7328.
25. Leyong Zeng, Da Lei, Weibiao Wang*, Jingqiu Liang, Zhiqian Wang, Ning Yao, Binglin Zhang. Preparation of carbon nanosheets deposited on carbon nanotubes by microwave plasma-enhanced chemical vapor deposition method. Applied Surface Science 2008, 254: 1700-1704.
26. Leyong Zeng, Weibiao Wang*, Da Lei, Jingqiu Liang, Haifeng Zhao, Jialong Zhao, Xianggui Kong. High field electron emission of carbon nanotubes grown on carbon fibers. Physica B 2008, 403:2662-2665. 

专著章节:
1. Leyong Zeng, Zheyu Shen, Aiguo Wu*.专著名称: Nanomaterials for Tumor Targeting Theranostics,第三章: Magnetic Nanomaterials for Tumor Targeting Theranostics. 出版社 Higher Education Press & World Scientifics 2015, Chap.3, 53-80。

申请(授权)专利:
1.曾乐勇, 吴爱国. 一种用于无机光动力治疗的复合纳米粒子及其制备方法。中国发明专利,授权专利号:ZL 201210172056.6.
2.曾乐勇,吴爱国,崔平. 顺磁-上转换发光复合纳米粒子及其制备方法和应用. 中国发明专利,授权专利号:ZL201110032000.6.
3.吴爱国,曾乐勇. Fe3O4复合TiO2纳米粒子及其制备方法以及在磁共振成像造影剂中的应用. 中国发明专利,授权专利号:ZL201010039632.0.
4.Leyong Zeng, Aiguo Wu, Ping Cui. Fe3O4-TiO2 nanocomposites: Preparation and application as contrast agents in magnetic resonance imaging. PCT国际专利,申请号:PCT/CN2010/077803.
5.吴爱国,曾乐勇,崔平. 纳米粒子和纳米粒子溶胶的制备方法及两者在磁共振成像造影剂中的应用. 中国发明专利,授权专利号:ZL201010175917.7.
6.吴爱国,曾乐勇,张付强,崔平. 水溶性具有核壳结构或核冕壳结构的材料的制备方法. 中国发明专利,授权专利号:ZL201110000844.2.
7.吴爱国,曾乐勇. 纳米材料或微纳器件的显微重复定位方法. 中国发明专利,授权专利号:ZL200910152441.2.
8.曾乐勇,吴爱国. 水溶液中阳离子的检测方法. 中国发明专利,申请号:200910152440.8.
9.张付强,吴爱国,曾乐勇. 金属离子的检测方法. 中国发明专利,授权专利号:ZL201010194041.0.
10.张付强,吴爱国,曾乐勇, 崔平. 利用ⅤA族或ⅥA族元素化合物检测金属阳离子的方法. 中国发明专利,授权专利号:ZL201010251278.8.
11.吴爱国,苗利静,沈折玉,曾乐勇.一种Cd2+的检测方法. 中国发明专利,授权专利号:ZL 20120391120.X.
12.梁中翥,梁静秋,王维彪,曾乐勇,方伟. 用于绝对测辐射热计上的金刚石复合膜片及其制备方法. 中国发明专利,授权专利号:ZL200810050500.
13.任文智,吴爱国,曾乐勇. 三元纳米复合药物、其制备方法和其用于制备治疗肿瘤的药学组合物的用途. 中国发明专利,申请号:2013101037757.
14.曾乐勇,吴爱国.一种核壳结构的复合纳米材料及其制法和应用。中国发明专利,申请号:201510405522.4 .