2023.12-至今, 中国科学院宁波材料技术与工程研究所,研究员
2020.11-2023.12,中国科学院宁波材料技术与工程研究所,副研究员
2018.07-2020.11,中国科学院宁波材料技术与工程研究所,博士后
(合作导师:吴爱国研究员)
2013.09-2018.07,北京航空航天大学化学学院,获材料物理与化学博士学位
(导师:郭 林教授)
2009.09-2013.07,东北师范大学物理学院,获物理学学士学位
林杰博士,中国科学院宁波材料所 研究员,博士生导师,先后入选中国科学院青促会会员、中国生物材料学会高级会员、中国复合材料学会高级会员、中国抗癌协会纳米肿瘤学专委会委员、中国抗癌协会诊疗一体化专委会委员、宁波市青年科技创新领军人才、宁波市领军与拔尖人才等。长期从事微纳米材料表面增强拉曼光谱(SERS)纳米生物传感器的基础和应用研究。通过材料表面缺陷态和表面非晶态提高半导体纳米材料作为纳米生物传感器的灵敏度,并通过 SERS 纳米生物传感器中的能级耦合效应实现传感器的选择性,将其与靶向抗体结合,构建兼具检测特异性、高光谱稳定性、主动式靶向能力的超高灵敏度 SERS 纳米生物传感器。发展了一系列新型的高性能 SERS 纳米生物传感器应用于肿瘤细胞检测/分型鉴定,研发的 SERS 探针试剂盒和配套检测仪器装备分别获得浙江省医疗器械注册检验报告(2 份;Z20230854, Z20242357)。近年来以第一/通讯作者(含共同)于Adv. Mater., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Anal. Chem., ACS Nano等期刊发表论文 47篇(封面论文 8 篇),共发表SCI收录论文 75篇,SCI 引用2400余次,H因子23,撰写 Wiley-vch 和 Elseriver英文专著章节 3 个,申请发明专利27项(PCT 3 项),获授权8项。作为项目负责人主持国家自然科学基金(面上、青年)、国家科技创新2030重大项目子课题、宁波市2025重大专项、中国博士后特别资助、企业/三甲医院横向技术服务等项目14项,受邀参加国内外学术会议并作邀请报告和分会主持30多次。
主要学术任职:
- 中国科学院青年促进创新会 化学与材料分会 委员
- 中国抗癌协会纳米肿瘤学专委会 委员
- 中国抗癌协会诊疗一体化专委会 委员
- 中国复合材料学会生物复合材料分会 委员
- 全国卫生产业企业管理协会健康医学 理事
- 浙江省转化医学会影像分会 委员
- 甬江人才工程领军拔尖人才培训项目医学与生命科学学科组工作委员会 委员
- SmartMat期刊 青年编委
- The Innovation期刊 青年编委
- Nano Biomedicine and Engineering期刊 青年编委
- Rare Metals期刊 青年编委
- VIEW期刊 青年编委
- BME Frontiers 期刊 青年编委
- Chinese Journal of Structural Chemistry期刊 青年编委
- 中国复合材料学会 高级会员
- 中国生物材料学会 高级会员
主要研究方向:
- 研究微纳米材料的表面物理化学电子结构与目标分子相互作用原理
- 设计和制备兼具灵敏度、稳定性及特异性的微纳米材料SERS生物探针
- 循环肿瘤细胞等循环肿瘤标志物的拉曼光谱组分学精准诊断
联系方式:电话:0574-63875030,E-mail:linjie@nimte.ac.cn
发表论文:
1. J. Lin, L. Guo*, et. al, Ultrasensitive SERS Detection by Defect Engineering on Single Cu2O Superstructure Particle, Adv. Mater., 2017, 29, 1604797.
2. J. Lin, A. G. Wu*, et. al, Amorphous Nitrogen-Doped Carbon Nanocages with Excellent SERS Sensitivity and Stability for Accurate Identification of Tumor Cells, Anal. Chem., 2023, 95, 4671-4681. (Cover)
3. X. Meng, J. Lin*, L. Guo*, et. al, SERS Detection of Trace Carcinogenic Aromatic Amines Based on Amorphous MoO3 Monolayers, Angew. Chem. Int. Ed. 2024,63,202407597.
4. J. Yu#, J. Lin#, L. Guo*, et. al, Au atoms anchored on amorphous C3N4 for single-site Raman enhancement, J. Am. Chem. Soc., 2022, 144, 21908-21915.
5. J. Y. Pei, J. Lin*, W. X. Chen*, et. al, Integrating Host Design and Tailored Electronic Effects of Yolk-Shell Zn-Mn Diatomic Sites for Efficient CO2 Electroreduction, Angew. Chem. Int. Ed. 2024, 63, e202316123
6. J. Lin*, A. G. Wu*, et. al, Multiple Valence States of Fe Boosting SERS Activity of Fe3O4 Nanoparticles and Enabling Effective SERS-MRI Bimodal Cancer Imaging, Fundam. Res., 2024, 4, 858-867.
7. Y. J. Xie, J. Lin*, A. G. Wu*, et. al, Synergistic Enhancement of Ultrahigh SERS Activity via Cu2O@Ag Core-Shell Structure for Accurate Label-free Identification of Breast Tumor Subtypes, Nano Today, 2024, 54, 102140.
8. H. F. Gu, J. Lin*, W. X. Chen*, et. al, Symmetry-Breaking p-Block Antimony Single Atoms Trigger N-Bridged Titanium Sites for Electrocatalytic Nitrogen Reduction with High Efficiency, ACS Nano, 2023, 17, 21838.
9. Y. J. Xie, J. Lin*, A. G. Wu*, et. al, Precise diagnosis of tumor cells and hemocytes via ultrasensitive, stable, selective cuprous oxide composite SERS bioprobe assisted with high efficiency separation microfluidic chip, Mater. Hor., 2024, DOI: 10.1039/D4MH00791C.
10. C. G. Zhang, A. G. Wu*, J. Lin* et. al, Machine Learning Assisted Dual-modal SERS Detection for Circulating Tumor Cells, Biosens. Bioelectron., 2025, 268, 116897.
11. X. Xu, J. Lin*, A. G. Wu*, et. al, TiO2-based Surface-Enhanced Raman Scattering Bio-probe for Efficient Circulating Tumor Cell Detection on Microfilter, Biosens. Bioelectron., 2022, 210, 114305.
12. M. J. Zhang, A. G. Wu*, X. T, Wang*, J. Lin*, et. al, A novel Fe2O3@CeO2 heterojunction substrate with high surface enhanced Raman scattering performance, SmartMat, 2024, DOI: 10.1002/smm2.1301.
13. J. Lin, L. Guo*, et. al, Direct Experimental Observation of Facet-Dependent SERS of Cu2O Polyhedra, Small, 2018, 14, 1703274.
14. Z. Sun#, J. Lin#, W. X. Chen*, et. al, Lattice Strain and Mott-Schottky Effect of Charge-Asymmetry Pd1Fe Single Atom Alloy Catalyst for Semi-Hydrogenation of Alkynes with High Efficiency, ACS Nano, 2024, 18, 13286.
15. J. Lin, A. G. Wu*, et. al, Low temperature-boosted high efficiency photoinduced charge transfer for remarkable SERS activity of ZnO nanosheets, Chem. Sci., 2020, 11, 9414. (Cover)
16. M. He#, J. Lin#,*, A. G. Wu*, et. al, Octahedral Silver Oxide Nanoparticles Enabling Remarkable SERS Activity for Circulating Tumor Cells Detection, Sci. China Life Sci., 2022, 65, 561.
17. T. Pan, J. Lin*, A. G. Wu*, et. al, PD-L1 targeted iron oxide SERS bioprobe for accurately detecting circulating tumor cells and delineating tumor boundary, Chinese Chem. Lett. 2024, DOI: 10.1016/j.cclet.2024.109857.
18. J. Wu, J. Lin*, A. R. Li*, et. al, Surface-enhanced Raman scattering on nanomaterials for cancer and pathogens diagnosis, Nano Res., 2024, Accept.
19. Y. Gao*, J. Lin*, Z. Liu*, et. al, Asymmetrically coordinated main group atomic In-S1N3 interface sites for promoting electrochemical CO2 reduction, Nano Res., 2024, 17, 5011.
20. Y. Yang#, J. Lin#, Lin Qiu*, et. al, A harmonicwave biothermal method for continuous monitoring skin thermal conductivity and capillary perfusion rate, Nano Res., 2023, 17,4420.
21. Z. Deng, J. Lin*, H. Zhai*, et. al, Electrocatalytic organic transformation reactions in green
chemistry: Exploring nanocrystals and single atom catalysts, Nano Res., 2024, DOI: 10.1007/s12274-024-6887-8.
22. X. Y. Meng, J. Lin*, X. T. Wang*, et. al, Significant surface-enhanced Raman scattering effect of Ag-loaded iron hydroxide enabled by coordination effect between Ag and hydroxyl group, Inorg. Chem. Front., 2023, 10, 3648.
23. Y. J. Xie, J. Lin*, A. G. Wu*, et. al, A Cubic Cu2O@Ag Bioprobe for Label-free SERS Classification of Hepatic Fibrosis and Hepatocellular Carcinoma, Mater. Chem. Front., 2024, 8, 2978 - 2988.
24. Y. Shang, X. T. Wang*, J. Lin*, “Delocalized π-bonds” Guided Pyramidal Nanocrystal Superstructures for Excellent Light Trapping in SERS, Mater. Chem. Front., 2024, DOI: 10.1039/D4QM00576G.
25. J. Lin, A. G. Wu*, et. al, Crystal-amorphous Core-shell Structure synergistically Enabling TiO2 Nanoparticles Remarkable SERS Sensitivity for Cancer Cells Imaging, ACS Appl. Mater. Inter., 2020, 12, 4204. (Cover)
26. X. Y. Meng, J. Lin*, X. T. Wang*, et. al, Ag-coated Ternary Layered Double Hydroxide as High-Performance SERS Sensor for Aldehydes, ACS Appl. Mater. Inter., 2023, 15, 41, 48818.
27. X. X. Wu, J. Lin*, A. G. Wu*, et. al, Stimuli-Responsive Co-Delivery System Self- Assembled from In-Situ Dynamic Covalent Reaction of Macrocyclic Disulfides for Cancer Magnetic Resonance Imaging and Chemotherapy, ACS Appl. Mater. Inter., 2023, 15, 44773.
28. Y. J. Xie, J. Lin* A. G. Wu*, et. al, Latest advances and perspectives of liquid biopsy for cancer diagnostics driven by microfluidic on chip assays, Lab on a chip, 2023, 23, 2922. (Cover)
29 A. Li#, J. Lin#, L. Guo*, et. al, Increased O 2p State Density Enabling Significant Photoinduced Charge Transfer for Surface-Enhanced Raman Scattering of Amorphous Zn(OH)2, J. Phys. Chem. Lett. 2020, 11, 1859.
30. A. Li#,J. Lin#, L. Guo*, et. al, Surface-Enhanced Raman Spectroscopy on Amorphous Semiconducting Rhodium Sulfide Microbowl Substrates, iScience, 2018, 14, 1703274.
31. J. Yu, J. Lin*, X. Wang*, et. al, Amorphous Co(OH)2 nanocages achieving efficient photo- induced charge transfer for significant SERS activity, J. Mater. Chem. C, 2022,10, 1632.
32. J. Lin, A. G. Wu*, et. al, Advances in surface-enhanced Raman scattering bioprobes for cancer imaging, VIEW, 2021, 20200146.
33. J. Lin, A. G. Wu*, et. al, An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy, J. Mater. Chem. B, 2020, 8, 3316
34. Gul Awiaz, J. Lin*, A. G. Wu*, Recent advances of Au@Ag core–shell SERS-based biosensors, Exploration, 2023, 3, 20220072.
授权专利:
- 林杰,吴爱国,陈天翔,马雪华“一种复合变价金属氧化物纳米粒子表面增强拉曼光谱的方法及应用” 授权-ZL202010897654.4。专利申请日:2020年08月31日,专利授权日:2023年4月7日
- 林杰,吴爱国,陈天翔,马雪华,何孟,徐夏薇“一种复合材料及其制备方法与应用”授权-ZL 202010898464.4。专利申请日:2020年08月31日,专利授权日:2024年2月27日
- 林杰,吴爱国,徐夏薇“一种循环肿瘤细胞筛选分离装置及方法和应用”,授权- ZL202010514536.0。专利申请日:2020年06月08日,专利授权日:2023年6月30日
- 林杰,吴爱国“ 一种超低温增强拉曼光谱信号的检测方法及应用” ,授权- ZL202010413729.7。专利申请日:2020年05月15日,专利授权日:2023年6月30日
- 马雪华,陈天翔,吴爱国,林杰,刘闯“一种杂化有机-金属框架磁性材料作为核磁共振造影剂的应用”,授权-ZL202010941706.3。专利申请日:2020年09月09日,专利授权日:2024年4月12日
- 吴爱国,胡佳鹏,陈天翔,林杰,房倩蓝,马雪华“一种铋系纳米异质结材料及其制备方法和应用”202110155796.8。授权-ZL202110155796.8。专利申请日:2021年02月04日,专利授权日:2022年10月28日
- 邵国良,张定虎, 林杰,吴爱国,武小侠“ 循环肿瘤细胞检测仪器”, 授权- ZL202230834356.0 专利申请日:2022年12月13日,专利授权日:2023年4月28日
- 吴爱国, 林杰, 张定虎,邵国良, 武小侠,李顺祥“ 探针试剂盒”, 授权-ZL 202230834025.7。专利申请日:2022年12月13日,专利授权日:2023年5月02日
主持项目:
- 国家自然科学基金面上项目,2024.01-2027.12,53万(在研 主持)
- 国家自然科学基金青年科学基金项目,2021.01-2023.12,24万(结题 主持)
- 国家科技创新2030重大项目子课题,2025.01-2027.12,100万(在研 主持)
- 中国科学院青年创新促进会会员,2023.01-2026.12,80万(在研 主持)
- 宁波市2025重大专项,2023.05-2026.04,200万(在研 主持)
- 宁波市青年科技领军创新人才 2024.01-2026.12,50万(在研 主持)
- 中科院宁波材料所“春蕾”人才 2023.01-2026.12,100万(在研 主持)