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任文智 高级工程师 硕士生导师
日期：2022-03-28， 查看：7582

2007.09 - 2010.06，上海师范大学微生物学专业，理学硕士学位。
2018.08 - 2019.06，中国科学院大学高分子化学与物理专业，获理学博士学位。
2010.06 - 2012.09，中国科学院宁波材料技术与工程研究所，科研助理。
2012.09 - 2018.12，宁波材料技术与工程研究所，助理研究员。
2018.12 - 至今，宁波材料技术与工程研究所，高级工程师。

    主要从事基于纳米探针的恶性肿瘤、心脑血管疾病诊断与治疗研究、无机-有机复合抗菌材料研究。目前，主持国家自然科学基金面上项目、浙江省及宁波市重点基金等10余项，以骨干或主要成员身份参与多项国家自然科学基金项目、中科院重点部署项目、浙江省重点研发计划等。是浙江省超声医学工程学会理事、浙江省抗癌协会核医学与分子影像专委会委员、中国生物物理协会会员、中国抗癌协会会员。在Bioactive Materials、Advanced Healthcare Materuals等国际权威期刊发表 SCI论文42篇；申请中国发明专利20余项，PCT专利2项，获授权8项。

研究方向：基于纳米探针材料的重大疾病早期诊断与治疗研究。 
联系方式：E-mail：renwzh@nimte.ac.cn

主持项目：

  1. 黑氧化钛光疗纳米探针调控动脉粥样硬化泡沫细胞脂质代谢研究. 国家自然科学基金，2022.01-2025.12， 57万
  2. 近红外二区激发的超小粒径bTiO2-Mn纳米探针肿瘤诊疗关键性能研究. 宁波市自然科学基金，2020.07-2023.06，20万
  3. 中空黑TiO2纳米探针的构建及其HIFU增效精准治疗肝癌研究. 浙江省自然科学基金，2019.01-2021.12， 10万
  4. 近红外光激发黑TiO2纳米粒子的肿瘤光热治疗与药物控释研究.浙江省自然科学基金，2015.01-2017.12， 8万
  5. 叶酸偶联的超顺磁Fe3O4-TiO2纳米粒子用于恶性肿瘤的MRI早期诊断与声动力治疗研究.宁波市自然科学基金，2014.03-2016.02，3万

主要论文：

  1. Ming Yang, Wenzhi Ren*, Haijing Cui, Qiongyu Qin, Qiuye Wang, Weihao Zhu, Xiaoxia Wu, Chunshu Pan, Xiaopeng Qi*, and Aiguo Wu*. Ginsenoside Rk1-loaded manganese-doped hollow titania for enhancing tumor sonodynamic therapy via upregulation of intracellular reactive oxygen species. ACS Appl. Mater. Interfaces 2023, doi.org/10.1021/acsami.3c03476.
  2. Qiongyu Qin, Ming Yang, Yu Shi, Haijing Cui, Chunshu Pan, Wenzhi Ren*, Aiguo Wu*, Jianqing Hu a*. Mn-doped Ti-based MOFs for magnetic resonance imaging-guided synergistic microwave thermal and microwave dynamic therapy of liver cancer. Bioactive Materials 2023, 27, 72–81.
  3. Shuangshuang Tu, Wenzhi Ren*, Jinru Han, Haijing Cui, Ting Dai, Haoxuan Lu, Yanqing Xie, Wenming He*, Aiguo Wu*. Polydopamine nanoparticle-mediated mild photothermal therapy for inhibiting atherosclerotic plaque progression by regulating lipid metabolism of foam cells. Regenerative Biomaterials, 2023, 10, rbad031.
  4. Hao Kong#, Jinru Han#, Ming Yang, Liangxue Lai, Yabing Sun, Xin Luan, Wenzhi Ren*, Aiguo Wu, Gang Wei*. Two-dimensional peptide nanosheets functionalized with gold nanorods for photothermal therapy of tumors. J. Mater. Chem. B, 2023,11, 3445.
  5. Ting Dai#; Wenming# He; Shuangshuang Tu; Jinru Han; Bo Yuan; Chenyang Yao; Wenzhi Ren*; Aiguo Wu*. Black TiO2 nanoprobe-mediated mild phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosis, Bioactive Materials, 2022, 17: 18-28.
  6. Shuangshuang Tu; Wenming He; Jinru Han; Aiguo Wu; Wenzhi Ren. Advances in imaging and treatment of atherosclerosis based on organic nanoparticles, APL Bioengineering, 2022, 6, 041501.
  7. Kaiwei Xu#; Lufei Jin#; Liu Xu#; Yuchao Zhu; Lu Hong; Chunshu Pan; Yanying Li; Junlie Yao; Ruifen Zou; Weiwei Tang; Jianhua Wang*; Aiguo Wu*; Wenzhi Ren*. IGF1 receptor-targeted black TiO2 nanoprobes for MRI-guided synergetic photothermal-chemotherapy in drug resistant pancreatic tumor, Journal of Nanobiotechnology, 2022, 20(1): 315.
  8. Qiuye Wang; Haijing Cui; Ning Gan; Xuehua Ma*; Wenzhi Ren*; Aiguo Wu*. Recent advances in matrix metalloproteinasesresponsive nanoprobes for cancer diagnosis and therapy. Reviews in Analytical Chemistry, 2022; 41: 198–216.
  9. Tao Zhang; Bihan Wu; Ozioma Udochukwu Akakuru; Chenyang Yao; Shan Sun; Libin Chen; WenzhiRen*; Aiguo Wu*; Pintong Huang*. Hsp90 inhibitor-loaded IR780 micelles for mitochondria-targeted mild-temperature photothermal therapy in xenograft models of human breast cancer, Cancer Letters, 2021, 500: 41-50.
  10. Ting Dai#; Wenming He#; Chenyang Yao; Xuehua Ma; Wenzhi Ren*; Yifeng Mai*; Aiguo Wu*.Applications of inorganic nanoparticles in the diagnosis and therapy of atherosclerosis, Biomaterials Science, 2020, 8: 3784-3799.
  11. Tao Zhang#, Zhenqi Jiang#, Libin Chen#, Chunshu Pan, Shan Sun, Chuang Liu, Zihou Li, Wenzhi Ren*, Aiguo Wu*, Pintong Huang*.PCN-Fe(III)-PTX nanoparticles for MRI guided high efficiency chemo-photodynamic therapy in pancreatic cancer through alleviating tumor hypoxia, Nano Research, 2020, 13: 273-281.
  12. Jie Lin#, Wenzhi Ren#, Anran Li#, Chenyang Yao, Tianxiang Chen, Xuehua Ma, Xiaotian Wang*, Aiguo Wu*, Crystal-amorphous core-shell structure synergistically enabling TiO2 nanoparticles’ remarkable SERS sensitivity for cancer cell imaging, ACS Appl. Mater. Interfaces, 2020, 12: 4204-4211. (#co-first author)
  13. Siqi Wang#, Wenzhi Ren#, Jianhua Wang,* Zhenqi Jiang, Madiha Saeed, Lili Zhang, Aiguo Li, Aiguo Wu*. Black TiO2-based nanoprobes for T1-weighted MRI-guided photothermal therapy in CD133 high expressed pancreatic cancer stem-like cells. Biomater. Sci., 2018, 6: 2209-2218.
  14. Madiha Saeed#, Wenzhi Ren#, Aiguo Wu. Therapeutic applications of iron oxide based nanoparticles in cancer: basic concepts and recent advances. Biomater. Sci., 2018, 6, 708-725.
  15. Wenzhi Ren, M. Zubair Iqbal, Leyong Zeng, Tianxiang Chen, Yuanwei Pan, Jinshun Zhao, Hao Yin, Lili Zhang, Jichao Zhang, Aiguo Li, Aiguo Wu*, Black TiO2 based core–shell nanocomposites as doxorubicin carriers for thermal imaging guided synergistic therapy of breast cancer, Nanoscale, 2017, 9: 11195-1120.
  16. Wenzhi Ren#, Yong Yan#, Leyong Zeng, Zhenzhi Shi, An Gong, Peter Schaaf, Dong Wang*, Jinshun Zhao, Baobo Zou, Hongsheng Yu, Ge Chen*, Eric Michael Bratsolias Brown, and Aiguo Wu*. A near infrared light triggered hydrogenated black TiO2 for cancer photothermal therapy. Adv. Healthcare Mater., 2015, ,4, 1526–1536. (back cover；cited 285 in Google Scholar )
  17. Yang Du#, Wenzhi Ren#, Yaqian Li, Qian Zhang, Leyong Zeng, Chongwei Chi,  Aiguo Wu*, Jie Tian*. The enhanced chemotherapeutic effects of doxorubicin loaded PEG coated TiO2 nanocarriers in an orthotopic breast Tumor bearing mouse model. Journal of Materials Chemistry B, 2015, 3, 1518-1528. (#co-first author; 2015 Journal of Materials Chemistry B Hot Papers)
  18. Wenzhi Ren, Leyong Zeng, Zheyu Shen, Lingchao Xiang, An Gong, Jichao Zhang, Chengwen Mao, Aiguo Li, Tatjana Paunesu, Gayle E. Woloschak, Narayan S. Hosmane, Aiguo Wu*. Enhanced doxorubicin transport to multidrug resistant breast cancer cells via TiO2 nanocarriers, RSC Advances, 2013, 3: 20855-20861

专著

    Aiguo Wu; Wenzhi Ren; TiO2 Nanoparticles：Applications in Nanobiotechnology and Nanomedicine. WILEY-VCH, 2020.

已申请或授权的主要专利：

  1. 任文智，吴爱国，一种基于纳米粒子的肿瘤细胞主动靶向给药体系及其构建方法，授权号：ZL201110397312.7
  2. 任文智，吴爱国，曾乐勇，沈折玉，马雪华，三元纳米复合药物、其制备方法和其用于制备治疗肿瘤的药学组合物的用途，授权号：ZL201310103775.7
  3. 任文智，吴爱国，一种肿瘤治疗复合纳米材料及其制备，授权号：ZL201410175018.5
  4. 任文智，吴爱国，马雪华，陈天翔，张涛，一种纳米复合材料、其制备方法及在HIFU增效剂中的应用，申请号：201810429878.5
  5. 吴爱国, 任文智, 邹瑞芬，一种纳米复合材料及其在示踪淋巴结中的应用,申请号：201710092810.8
  6. 沈折玉，吴爱国，任文智，马雪华，主动靶向性小干扰核糖核酸输送载体及其制备方法，授权号：ZL201210475752.4
  7. 张涛，吴爱国，任文智，蒋振奇，薛婷，马雪华，一种纳米复合材料、其制备方法及应用，专利申请号：201810907829.8