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李娟 研究员 博士生导师
日期：2022-04-01， 查看：39577


 

2000.10-2004.07 沈阳药科大学药物化学专业，获工学学士学位.
2004.09-2007.07 沈阳药科大学药物分析专业，获理学硕士学位
2008.11-2012.09 德国马普生物控制所/德国图宾根大学药学专业，获博士学位
2012.10-2014.09 中国科学院宁波材料技术与工程研究所，博士后/助理研究员
2014.12-2018.11 中国科学院宁波材料技术与工程研究所，副研究员
2018.12-2020.11 中国科学院宁波材料技术与工程研究所，项目研究员
2020.12-至今 中国科学院宁波材料技术与工程研究所，研究员

主要从事神经肽生物材料设计与应用研究，曾主持国家自然科学基金5项（优青、面上、国际合作等）、科技部重点研发计划“诊疗装备与生物医用材料”青年科学家项目；参与国家重点研发计划“精准医学研究”专项、浙江省重点研发计划、中科院重点部署等项目。以第一作者或通讯作者在Adv Mater、ACS Nano、Nano Today、Biomaterials等国际期刊发表论文50余篇，申请国内外发明专利54项（含PCT专利3项），授权12项（瑞士1项，中国11项），受邀参加国内外学术会议并作邀请报告和分会主持20次。英国皇家化学会JMCB期刊新锐科学家、中科院青促会优秀会员、荣获宁波市青年科技奖等。目前是国际神经科学协会会员、中国抗癌协会纳米肿瘤专业委员会委员/青委会副主委、中国超声医学工程学会超声治疗及生物学效应专业委员会委员、中国医药生物技术协会生物医学成像技术分会委员等。

研究方向：1. 纳米生物材料在肿瘤及神经系统的成像与治疗研究
                 2. 多肽及小分子配体药物设计与应用研究
                 3. 近红外荧光分子探针设计与应用研究

联系方式：E-mail：lij@nimte.ac.cn

发表文章：

  1. Xiaolin Duan, Pin Wang, Lulu He, Zhen He, Shiwei Wang, Fang Yang, Changyong Gao, Wenzhi Ren, Jie Lin, Tianxiang Chen, Chen Xu, Juan Li(*) and Aiguo Wu(*), Peptide-Functionalized Inorganic Oxide Nanomaterials for Solid Cancer Imaging and Therapy, Advanced Materials 2024, 2311548.
  2. Yi Cao, Xiaojiao Ge, Xueli Zhu, Yingying Han, Pin Wang, Ozioma Udochukwu Akakuru, Aiguo Wu(*), Juan Li(*), Transformable neuropeptide prodrug with tumor microenvironment responsiveness for tumor growth and metastasis inhibition of triple‐negative breast cancer, Advanced Science, 2023, 2300545.
  3. Yuanbo Pan, Yang Zhu, Canxin Xu, Chunshu Pan, Yu Shi, Jianhua Zou, Yanying Li, Xueyin Hu, Bo Zhou, Chenyang Zhao, Qianqian Gao, Jianmin Zhang (*), Aiguo Wu (*), Xiaoyuan Chen (*), and Juan Li (*), Biomimetic Yolk–Shell Nanocatalysts for Activatable Dual-Modal-Image-Guided Triple-Augmented Chemodynamic Therapy of Cancer, ACS Nano 2022, 16：19038-19052.
  4. Yanying Li, Yuanbo Pan, Yinjie Wang, Zhenqi Jiang, Ozioma U. Akakuru, Mingli Li, Xianyun Zhang, Bo Yuan, Jie Xing, Lijia Luo, Dan Larhammar, Aiguo Wu, Juan Li (*); A D-peptide ligand of neuropeptide Y receptor Y1 serves as nanocarrier traversing of the blood brain barrier and targets glioma, Nano Today, 2022, 44: 101465.
  5. Yanying Li, Xuelu He, Pin Wang, Bo Yuan, Yuanbo Pan, Xueyin Hu, Liheng Lu, Aiguo Wu(*), Juan Li(*), A D-Y Shaped Neuropeptide Y Mimetic Peptide-Dye Self-Assembly with Maximal Emission Beyond 1300 nm and Glioma Mitochondrial Activity Modulation, Small, 2023, 2308621：1-7.
  6. Lulu He, Le Wang, Zhen He, Cheng Heng Pang, Bencan Tang, Aiguo Wu(*), Juan Li(*), Strategies for utilizing covalent organic frameworks as host materials for the integration and delivery of bioactives, Materials Horizons, 2024, 11, 1126–1151.
  7. Xuelu He, Yuan Luo, Yanying Li, Yuanbo Pan, Ryan T. K. Kwok, Lulu He, Xiaolin Duan, Pengfei Zhang(*), AiguoWu(*), Ben Zhong Tan(*), Juan Li(*), D-type neuropeptide decorated AIEgen/RENP hybrid nanoprobes with light-driven ROS generation ability for NIR-II fluorescence imaging-guided through-skull photodynamic therapy of gliomas, Aggregate, 2023, e396：1-11.    
  8. Yuanbo Pan (#), Canxin Xu (#), Hongzhang Deng, Qing You, Chenyang Zhao, Yanying Li, Qianqian Gao, Ozioma Udochukwu Akakuru, Juan Li (*), Jianmin Zhang(*), Aiguo Wu(*), Xiaoyuan Chen(*); Localized NIR-II laser mediated chemodynamic therapy of glioblastoma, Nano Today, 2022, 43: 101435.
  9. Xiaojiao Ge, Yi Cao, Xueli Zhu, Bo Yuan, Lulu He, Aiguo Wu(*), Juan Li(*), Self-Assembly of Organelle-Localized Neuropeptides Triggers Intrinsic Apoptosis Against Breast Cancer, Advanced Healthcare Materials, 2023, 12：2300265.
  10. Canxin Xu, Yuanbo Pan, Hongchi Zhang, Yuhao Sun, Yi Cao, Pengfei Qi, Mingli Li, Ozioma Udochukwu Akakuru, Lulu He, Chen Xiao, Bomin Sun, Liuguan Bian(*), Juan Li(*), Aiguo Wu(*), Platelet-Membrane-Coated Polydopamine Nanoparticles for Neuroprotection by Reducing Oxidative Stress and Repairing Damaged Vessels in Intracerebral Hemorrhag, Advanced Healthcare Materials, 2023, 12：2300797.
  11. Wenhao Lv (#), Chen Xu (#), Hao Wu, Yangyang Zhu, Ozioma Udochukwu Akakuru, Hui Du, Fang Nie(*), Aiguo Wu(*), Juan Li(*); Ultrasound-visualized nanocarriers with siRNA for targeted inhibition of M2-like TAM polarization to enhance photothermal therapy in NSCLC, Nano Research, 2023, 16: 882-893.
  12. Zhenqi Jiang(#), Xiao Han(#), Yang Du(#), Yanying Li, Yong Li, Juan Li (*), Jie Tian, (*) and Aiguo Wu (*), Mixed Metal Metal–Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging, Nano Letters, 2021, 21, 2730-2737.
  13. Zhenqi Jiang, Bo Yuan, Yinjie Wang, Zhenni Wei, Shan Sun, Ozioma Udochukwu Akakuru, Yong Li, Juan Li (*), Aiguo Wu (*), Near-infrared heptamethine cyanine dye-based nanoscale coordination polymers with intrinsic nucleus-targeting for low temperature photothermal therapy, Nano Today, 2020, 34: 100910.
  14. Ozioma Udochukwu Akakuru, Chuang Liu, M. Zubair Iqbal (*), Gohar Ijaz Dar, Gao Yang, Kun Qian, Elvis Ikechukwu Nosike, Jie Xing, Zhoujing Zhang, Yanying Li, Juan Li (*) and Aiguo Wu (*), A Hybrid Organo-Nanotheranostic Platform of Superlative Biocompatibility for Near-Infrared-Triggered Fluorescence Imaging and Synergistically Enhanced Ablation of Tumors, Small, 2020, 2002445.
  15. Zhenqi Jiang (#), Yinjie Wang (#), Li Sun, Bo Yuan, Yuchen Tian, Lingchao Xiang, Yanying Li, Yong Li, Juan Li (*), Aiguo Wu (*), Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo, Biomaterials, 2019, 197: 41-50.
  16. Zhenqi Jiang (#), Yuchen Tian (#), Dingying Shan, Yinjie Wang, Ethan Gerhard, Jianbi Xia, Rong Huang, Yan He, Aiguo Li, Jianchao Tang, Huimin Ruan, Yong Li, Jian Yang, Juan Li (*), Aiguo Wu (*), pH protective Y1 receptor ligand functionalized antiphagocytosis BPLP-WPU micelles for enhanced tumor imaging and therapy with prolonged survival time, Biomaterials, 2018, 170: 70-81.
  17. Juan Li (#), Yuchen Tian (#), Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang and Aiguo Wu (*). Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging. Biomaterials, 2017, 116: 106-117.
  18. Yinjie Wang (#), Yi Cao (#), Zhenqi Jiang, Yanying Li, Bo Yuan, Jie Xing, Mingli Li, Qianqian Gao, Kaiwei Xu, Ozioma Udochukwu Akakuru, Aiguo Wu (*), Juan Li (*); The neuropeptide Y1 receptor ligand-modified cell membrane promotes targeted photodynamic therapy of zeolitic imidazolate frameworks for breast cancer, The Journal of Physical Chemistry Letters, 2021, 46: 11280-11287.
  19. Xuelu He (#), Zhenqi Jiang (#), Ozioma Udochukwu Akakuru, Juan Li (*), Aiguo Wu (*); Nanoscale covalent organic frameworks: from controlled synthesis to cancer therapy, Chemical Communications, 2021, 57: 12417-12435.
  20. Zhenqi Jiang (#), Bo Yuan (#), Nianxiang Qiu, Yinjie Wang, Li Sun, Zhenni Wei, Yanyin Li, Jianjun Zheng, Yinhua Jin, Yong Li, Shiyu Du, Juan Li (*), Aiguo Wu (*), Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy, Nano-Micro Letters, 2019, 11, 61.
  21. Zhenqi Jiang, Yanying Li, Zhenni Wei, Bo Yuan, Yinjie Wang, Ozioma Udochukwu Akakuru, Yong Li, Juan Li (*), Aiguo Wu (*). Pressure-induced amorphous zeolitic imidazole frameworks with reduced toxicity and increased tumor accumulation improves therapeutic efficacy In vivo. Bioactive Materials, 2021, 6: 740-748.
  22. Juan Li (#), Yang Du (#), Zhenqi Jiang, Yuchen Tian, Nianxiang Qiu, Yinjie Wang, Muhammad Zubair lqbal, Menying Hu, Ruifen Zou, Lijia Luo, Shiyu Du, Jie Tian (*), Aiguo Wu (*), Y1 receptor ligand-based nanomicelle as a novel nanoprobe for glioma-targeted imaging and therapy, Nanoscale, 2018, 10: 5845-5851.  
  23. Zhangsen Yu, Yuanzhi Xia, Jie Xing, Zihou Li, Jianjun Zhen, Yinhua Jin, Yuchen Tian, Chuang Liu, Zhenqi Jiang, Juan Li (*), Aiguo Wu (*), Y1-receptor-ligand-functionalized ultrasmall upconversion nanoparticles for tumor targeted trimodality imaging and photodynamic therapy with low toxicity, Nanoscale, 2018, 10: 17038-17052.
  24. Juan Li, Zheyu Shen, Xuehua Ma, Wenzhi Ren, Lingchao Xiang, An Gong, Tian Xia, Junming Guo, Aiguo Wu (*). Neuropeptide Y Y1 receptors meditate targeted delivery of anticancer drug with encapsulated nanoparticles to breast cancer cells with high selectivity and its potential for breast cancer therapy. ACS Applied Materials & Interfaces, 2015, 7: 5574-5582.
  25. Yinjie Wang (#), Zhenqi Jiang (#), Bo Yuan, YuchenTian, Lingchao Xiang, Yanying Li, Yong Yang, Juan Li (*), Aiguo Wu (*). Y1 receptor ligand synergized with P-glycoprotein inhibitor improves therapeutic efficacy of multidrug resistant breast cancer. Biomaterials Science, 2019, 7: 4748-4757.
  26. Xuechen Qian (#), Yinjie Wang (#), Youfeng Xu, Ling Ma, Nianyu Xue, Zhenqi Jiang, Yi Cao, Ozioma Udochukwu Akakuru, Juan Li (*), Shengmin Zhang (*) and Aiguo Wu (*), Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer, Journal of Materials Chemistry B, 2020, 8: 6837.
  27. Linzi Chen (#), Zhenqi Jiang (#), Ozioma Udochukwu Akakuru, Lifei Yang, Juan Li (*), Suya Ma (*), Aiguo Wu (*), Recent progress in the detection and treatment of atherosclerosis by nanoparticles, Materials Today Chemistry, 2020, 17: 100280.
  28. Juan Li (*), Yuchen Tian, Aiguo Wu (*)，Neuropeptide Y receptors: a promising target for cancer imaging and therapy, Regenerative Biomaterials, 2015, 2: 215-219.

授权与申请专利：

  1. 瑞士专利，李娟，吴爱国，主动靶向型抗肿瘤药物及其制备方法，授权，CH 710 313 B1
  2. 中国专利，李娟，吴爱国，田宇辰，主动靶向型抗脑肿瘤药物及其制备方法，授权，ZL201510535764.5
  3. 中国专利，李娟，吴爱国，主动靶向型抗肿瘤药物及其制备方法，授权，ZL201310407938.0
  4. 中国专利，李娟，蒋振奇，吴爱国，王胤杰，袁博，房倩兰，李彦莹，一种抗癌药物复合物及其制备方法和应用，授权，ZL 201711209793.8
  5. 中国专利，沈折玉，吴爱国，马雪华，龚安，任文智，李娟，靶向型诊疗联用药物及其制备方法和应用，授权，ZL 201310318107.6
  6. 中国专利，李娟，田宇辰，吴爱国, 一种主动靶向型超声/荧光双模态造影剂及其制备方法和应用，授权，ZL201610235965.8
  7. 中国专利，吴爱国，蒋振奇，袁博，李娟, 一种七甲川硝基吲哚花菁染料以及该染料的制备方法和用途，授权，ZL201910175647.0
  8. 中国专利，吴爱国，蒋振奇，李娟，王胤杰，袁博，项灵超，李彦莹, 沸石咪唑框架结构材料的制备方法，授权，ZL201810007681.2
  9. 美国专利，李娟，吴爱国，主动靶向型抗肿瘤药物及其制备方法，申请，14/917,256
  10. 德国专利，李娟，吴爱国，主动靶向型抗肿瘤药物及其制备方法，申请，112014004133.5
  11. 中国专利，李娟，吴爱国，主动靶向型抗肿瘤药物及其制备方法，申请，PCT/CN2014/075727

主持和参与项目：

  1. 国家科技部重点研发计划“诊疗装备与生物医用材料”青年科学家项目，2023.11-2026.10，200万元，在研，主持
  2. 国家自然科学基金优秀青年基金，2023.01-2025.01，200万元，在研，主持
  3. 国家自然科学基金面上项目，2019.01-2022.12，结题，项目负责人
  4. 国家自然科学基金委员会与瑞典科研与教育国际合作基金会合作交流项目，2020.07-2023.06，在研，项目负责人
  5. 国家自然科学基金委员会-广东省政府联合基金超级计算科学应用研究专项，2016.01-2017.12，结题，项目负责人
  6. 国家自然科学基金青年基金，2013.01-2016.12，结题，项目负责人
  7. 宁波市2025重大专项，2021.07-2024.07，在研，项目负责人
  8. 国家重点研发计划“精准医学专项”，2018.07-2020.12，结题，项目骨干
  9. 浙江省重点研发计划，2020.01-2023.12，在研，项目骨干
  10. 浙江省公益技术应用研究项目，2016.01-2018.12，结题，项目负责人